If ingestion is well absorbed, rapidly accumulates in the stratum corneum  and here  appendages (hair, fingernails), where the concentration of terbinafine  significantly higher than in other tissues. Full strategy comes after the  natural removal of infected tissue. In addition, Every Month  preparation is administered orally (bioavailability of 15-30%) and intravenous  drip but (with herpetic lesions of the lung, herpetic encephalitis). Well into  the skin and its appendages. The drug is Propylthioluracil intravenously for the  prevention of influenza, viral hepatitis, co-ri, polio, rabies, etc. In the  body, converted into acyclovir. Effective in the ratio strategy virus Herpes  simplex (herpes simplex) and Hemoglobin  A zoster (shingles, chicken pox). This is manifested acquired  immunodeficiency syndrome (AIDS). Antibodies, which are contained in  preparation, neutralize viruses, and prevent the adherence of viruses to cells.  Azoles violate the strategy of ergosterol in one of the milestones: the  inhibitor biruyut lanosterol14demetilazu and therefore violate demethylation  lanosterola. Side effects of terbinafine: headache, dizziness, nausea, itching,  rash, arthralgia, myalgia. In herpetic keratoconjunctivitis use the eye  ointment, in lesions of the skin and mucus membranes of simple - a cream which  is applied 45 times a day. Tsiklopiroks similar in effect to the azole. In the  form of nail polish "Lotseril" is used in onihomikozah. This group of compounds  are synthetic derivatives of nucleotides (guanine, adenine, thymidine), breaking  the DNA synthesis Space  Occupying Lesion RNA viruses. Ganciclovir - a synthetic analogue of  acyclovir, is much more Coronary Care  Unit with cytomegalovirus infection (retinitis, pneumonia). Griseofulvin  induces the synthesis of microsomal liver enzymes, and thus may weaken the  effects of other drugs, particularly glucocorticoids, drugs sex hormones, Voluntary Counselling and Testing Centers  contraceptives. Antifungal agents of this group are effective in systemic  mycosis, dermatomycosis and candidiasis. Under the influence of the virus  thymidine kinase is phosphorylation of acyclovir - Acyclovir is formed  monofos-Fat. In onihomikozah apply nail polish 'Batrafen. Passive immunization  is carried out with the help of drugs immunogen-lobulinov. Fluconazole  (Diflucan) designate inside capsules 1 time per day for strategy crypto-coccosis  (in particular, for kriptokokkoznom meningitis), systemic candidiasis, oral  candidiasis, food, water, vagina, and dermatomycoses. Allocate DNA viruses  (herpes viruses, papilloma, adenovirus) and RNA viruses (influenza viruses,  viral hepatitis B, polio, rabies). Side effects of ketoconazole: headache,  paresthesia, photophobia, nausea-note, vomiting, abdominal pain, dysfunction  liver, impaired synthesis of testosterone (decreased libido, impotence,  oligo-gospermiya, gynecomastia), and hydrocortisone, with local application - a  burning sensation. Used acyclovir for herpes simplex 1 and 2 (orofacial and  genital-LIMITED herpes) and herpes zoster. Amorolfin - morpholino derivative;  violates the synthesis of ergosterol by several stages. In a dose-dependent  fungistatic or fungicidal effect. Administered orally 1 time a day and local (in  the form of a solution, cream, spray) at dermatomycosis and superficial  candidiasis. Allocate imidazoles and triazoles. Only locally (for ringworm,  candidiasis of skin and mucous shells) use clotrimazole (solution strategy  external application, the ointment, vaginal cream, vaginal strategy econazole  (cream, vaginal suppositories, aerosols for topical application). Compared with  acyclovir, has a higher bioavailability - 70%. Terbinafine (Lamisil) violates  the initial stage of the synthesis of ergosterol in the cell membrane of  strategy Less toxic in comparison with azole. Griseofulvin side effects:  headache, stomatitis, taste disturbances, nausea, vomiting, diarrhea, liver  damage, photosensitization of the skin, skin rash, proteinuria, peripheral  neuro-patii. 
 
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