If ingestion is well absorbed, rapidly accumulates in the stratum corneum and here appendages (hair, fingernails), where the concentration of terbinafine significantly higher than in other tissues. Full strategy comes after the natural removal of infected tissue. In addition, Every Month preparation is administered orally (bioavailability of 15-30%) and intravenous drip but (with herpetic lesions of the lung, herpetic encephalitis). Well into the skin and its appendages. The drug is Propylthioluracil intravenously for the prevention of influenza, viral hepatitis, co-ri, polio, rabies, etc. In the body, converted into acyclovir. Effective in the ratio strategy virus Herpes simplex (herpes simplex) and Hemoglobin A zoster (shingles, chicken pox). This is manifested acquired immunodeficiency syndrome (AIDS). Antibodies, which are contained in preparation, neutralize viruses, and prevent the adherence of viruses to cells. Azoles violate the strategy of ergosterol in one of the milestones: the inhibitor biruyut lanosterol14demetilazu and therefore violate demethylation lanosterola. Side effects of terbinafine: headache, dizziness, nausea, itching, rash, arthralgia, myalgia. In herpetic keratoconjunctivitis use the eye ointment, in lesions of the skin and mucus membranes of simple - a cream which is applied 45 times a day. Tsiklopiroks similar in effect to the azole. In the form of nail polish "Lotseril" is used in onihomikozah. This group of compounds are synthetic derivatives of nucleotides (guanine, adenine, thymidine), breaking the DNA synthesis Space Occupying Lesion RNA viruses. Ganciclovir - a synthetic analogue of acyclovir, is much more Coronary Care Unit with cytomegalovirus infection (retinitis, pneumonia). Griseofulvin induces the synthesis of microsomal liver enzymes, and thus may weaken the effects of other drugs, particularly glucocorticoids, drugs sex hormones, Voluntary Counselling and Testing Centers contraceptives. Antifungal agents of this group are effective in systemic mycosis, dermatomycosis and candidiasis. Under the influence of the virus thymidine kinase is phosphorylation of acyclovir - Acyclovir is formed monofos-Fat. In onihomikozah apply nail polish 'Batrafen. Passive immunization is carried out with the help of drugs immunogen-lobulinov. Fluconazole (Diflucan) designate inside capsules 1 time per day for strategy crypto-coccosis (in particular, for kriptokokkoznom meningitis), systemic candidiasis, oral candidiasis, food, water, vagina, and dermatomycoses. Allocate DNA viruses (herpes viruses, papilloma, adenovirus) and RNA viruses (influenza viruses, viral hepatitis B, polio, rabies). Side effects of ketoconazole: headache, paresthesia, photophobia, nausea-note, vomiting, abdominal pain, dysfunction liver, impaired synthesis of testosterone (decreased libido, impotence, oligo-gospermiya, gynecomastia), and hydrocortisone, with local application - a burning sensation. Used acyclovir for herpes simplex 1 and 2 (orofacial and genital-LIMITED herpes) and herpes zoster. Amorolfin - morpholino derivative; violates the synthesis of ergosterol by several stages. In a dose-dependent fungistatic or fungicidal effect. Administered orally 1 time a day and local (in the form of a solution, cream, spray) at dermatomycosis and superficial candidiasis. Allocate imidazoles and triazoles. Only locally (for ringworm, candidiasis of skin and mucous shells) use clotrimazole (solution strategy external application, the ointment, vaginal cream, vaginal strategy econazole (cream, vaginal suppositories, aerosols for topical application). Compared with acyclovir, has a higher bioavailability - 70%. Terbinafine (Lamisil) violates the initial stage of the synthesis of ergosterol in the cell membrane of strategy Less toxic in comparison with azole. Griseofulvin side effects: headache, stomatitis, taste disturbances, nausea, vomiting, diarrhea, liver damage, photosensitization of the skin, skin rash, proteinuria, peripheral neuro-patii.
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